Hepatocyte injury: swelling (ballooning degeneration)
Cholestasis: canalicular bile plugs
HCV: mild focal fatty change of hepatocytes
Hepatocyte necrosis: isolated cells or clusters
Cytolysis (rupture) or apoptosis forming Councilman bodies
If severe: bridging necrosis (portal-portal, central-central, portal-central)
Lobular disarray: loss of normal architecture
Regenerative changes: hepatocyte proliferation
Sinusoidal cell reactive changes:
Accumulation of phagocytosed cellular debris in Kupffer cells
Influx of mononuclear cells into sinusoids
Portal tracts:
Inflammation: 1)predominantly mononuclear
2)Inflammatory spillover into adjacent parenchyma, with hepatocyte necrosis.